Penicillin

Penicillin is a bold, smooth whisky cocktail recipe with fresh citrus, gentle spice, and a soft honey finish. It tastes bright, warming, and balanced, making every sip feel refined and easy to enjoy. If you want to learn how to make a modern classic with rich flavor and a polished feel, this cocktail recipe is a great place to start.

Glass

Rocks glass

Prep Time

5 min

Difficulty

Medium

Alchol

Ingredients

1

2 oz blended Scotch whisky

2

3/4 oz fresh lemon juice

3

3/4 oz honey ginger syrup

4

1/4 oz Islay Scotch whisky

5

Garnish: candied ginger

Steps

1

Step 1

Fill a shaker with ice, then add whisky, lemon juice, and honey ginger syrup.
2

Step 2

Shake well until the mixture is thoroughly chilled and properly combined.
3

Step 3

Strain into a rocks glass over fresh ice.
4

Step 4

Float smoky Scotch on top by gently pouring it over the back of a spoon.
5

Step 5

Garnish with candied ginger and serve immediately.

Flavor Profile

History

The Penicillin cocktail was created in the mid 2000s by bartender Sam Ross at Milk and Honey in New York City. Inspired by classic whisky sours and smoky Scotch flavors, it quickly became a modern classic known for its bold yet balanced character. Its name references the famous medicine, giving the drink a memorable identity in contemporary cocktail culture.

FAQ

What is a Penicillin cocktail made of?
A Penicillin is typically made with blended Scotch, fresh lemon juice, honey ginger syrup, and a float of smoky Islay Scotch on top. The result is bright, lightly sweet, spicy, and smoky.
Does a Penicillin cocktail contain penicillin or any medicine?
No, the drink does not contain penicillin or any medicinal ingredient. The name is playful, but it is simply a modern Scotch based cocktail.
How strong is a Penicillin cocktail?
A Penicillin is moderately strong since it uses Scotch as the base spirit and usually a second Scotch float. Its exact strength depends on the pour, but it is generally similar in strength to other spirit forward sours.
What does a Penicillin cocktail taste like?
It tastes smoky, citrusy, and gently sweet with a warm ginger kick. The balance of honey, lemon, and Scotch gives it a bold but very approachable flavor.
Can I make a Penicillin without Islay Scotch?
Yes, you can make it without Islay Scotch if you prefer a less smoky drink. Use your regular blended Scotch only, or add a small amount of another smoky whisky if you want a lighter version.
What is the best Scotch for a Penicillin cocktail?
A blended Scotch works well for the main base because it keeps the drink smooth and balanced. For the float, many people choose an Islay Scotch to add the signature smoky aroma.